PCDHGA3 Antibody (Center) Blocking peptide
€363.00
In stock
SKU
AC-BP13611c
Background:
This gene is a member of the protocadherin gamma genecluster, one of three related clusters tandemly linked onchromosome five. These gene clusters have an immunoglobulin-likeorganization, suggesting that a novel mechanism may be involved intheir regulation and expression. The gamma gene cluster includes 22genes divided into 3 subfamilies. Subfamily A contains 12 genes,subfamily B contains 7 genes and 2 pseudogenes, and the moredistantly related subfamily C contains 3 genes. The tandem array of22 large, variable region exons are followed by a constant region,containing 3 exons shared by all genes in the cluster. Eachvariable region exon encodes the extracellular region, whichincludes 6 cadherin ectodomains and a transmembrane region. Theconstant region exons encode the common cytoplasmic region. Theseneural cadherin-like cell adhesion proteins most likely play acritical role in the establishment and function of specificcell-cell connections in the brain. Alternative splicing has beendescribed for the gamma cluster genes.
Other Names:
Protocadherin gamma-A3, PCDH-gamma-A3, PCDHGA3
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP13611c was selected from the Center region of PCDHGA3. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: PCDHGA3
Gene ID: 56112
Primary Accession: Q9Y5H0
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
This gene is a member of the protocadherin gamma genecluster, one of three related clusters tandemly linked onchromosome five. These gene clusters have an immunoglobulin-likeorganization, suggesting that a novel mechanism may be involved intheir regulation and expression. The gamma gene cluster includes 22genes divided into 3 subfamilies. Subfamily A contains 12 genes,subfamily B contains 7 genes and 2 pseudogenes, and the moredistantly related subfamily C contains 3 genes. The tandem array of22 large, variable region exons are followed by a constant region,containing 3 exons shared by all genes in the cluster. Eachvariable region exon encodes the extracellular region, whichincludes 6 cadherin ectodomains and a transmembrane region. Theconstant region exons encode the common cytoplasmic region. Theseneural cadherin-like cell adhesion proteins most likely play acritical role in the establishment and function of specificcell-cell connections in the brain. Alternative splicing has beendescribed for the gamma cluster genes.
Other Names:
Protocadherin gamma-A3, PCDH-gamma-A3, PCDHGA3
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP13611c was selected from the Center region of PCDHGA3. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: PCDHGA3
Gene ID: 56112
Primary Accession: Q9Y5H0
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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