PCDHGA5 antibody (clone 5H5), anti-human
€435.00
In stock
SKU
AC-AT3228a
Catalog Number: AC-AT3228a
Size: 100 µg
Isotype: mouse IgG2a Kappa
Applications: WB, E
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Size: 100 µg
Isotype: mouse IgG2a Kappa
Applications: WB, E
Request Information AC-AT3228a">Request Information
Background:
This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes.
Other Names:
Protocadherin gamma-A5, PCDH-gamma-A5, PCDHGA5
Antigen Type:
Recombinant Protein
Gene Name: PCDHGA5
Gene ID: 56110
NCBI Accession: NP_061741.1;NP_114443.1
Primary Accession: Q9Y5G8
Other Accession: NM_018918
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes.
Other Names:
Protocadherin gamma-A5, PCDH-gamma-A5, PCDHGA5
Antigen Type:
Recombinant Protein
Gene Name: PCDHGA5
Gene ID: 56110
NCBI Accession: NP_061741.1;NP_114443.1
Primary Accession: Q9Y5G8
Other Accession: NM_018918
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
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