PCDHGB4 Antibody (Center) Blocking Peptide
€363.00
In stock
SKU
AC-BP18848c
Background:
This gene is a member of the protocadherin gamma genecluster, one of three related clusters tandemly linked onchromosome five. These gene clusters have an immunoglobulin-likeorganization, suggesting that a novel mechanism may be involved intheir regulation and expression. The gamma gene cluster includes 22genes divided into 3 subfamilies. Subfamily A contains 12 genes,subfamily B contains 7 genes and 2 pseudogenes, and the moredistantly related subfamily C contains 3 genes. The tandem array of22 large, variable region exons are followed by a constant region,containing 3 exons shared by all genes in the cluster. Eachvariable region exon encodes the extracellular region, whichincludes 6 cadherin ectodomains and a transmembrane region. Theconstant region exons encode the common cytoplasmic region. Theseneural cadherin-like cell adhesion proteins most likely play acritical role in the establishment and function of specificcell-cell connections in the brain. This particular family memberis expressed in fibroblasts and is thought to play a role in woundhealing in response to injury. Alternative splicing has beendescribed for the gamma cluster genes.
Other Names:
Protocadherin gamma-B4, PCDH-gamma-B4, Cadherin-20, Fibroblast cadherin-2, PCDHGB4, CDH20, FIB2
Gene Name: PCDHGB4
Gene ID: 8641
Primary Accession: Q9UN71
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
This gene is a member of the protocadherin gamma genecluster, one of three related clusters tandemly linked onchromosome five. These gene clusters have an immunoglobulin-likeorganization, suggesting that a novel mechanism may be involved intheir regulation and expression. The gamma gene cluster includes 22genes divided into 3 subfamilies. Subfamily A contains 12 genes,subfamily B contains 7 genes and 2 pseudogenes, and the moredistantly related subfamily C contains 3 genes. The tandem array of22 large, variable region exons are followed by a constant region,containing 3 exons shared by all genes in the cluster. Eachvariable region exon encodes the extracellular region, whichincludes 6 cadherin ectodomains and a transmembrane region. Theconstant region exons encode the common cytoplasmic region. Theseneural cadherin-like cell adhesion proteins most likely play acritical role in the establishment and function of specificcell-cell connections in the brain. This particular family memberis expressed in fibroblasts and is thought to play a role in woundhealing in response to injury. Alternative splicing has beendescribed for the gamma cluster genes.
Other Names:
Protocadherin gamma-B4, PCDH-gamma-B4, Cadherin-20, Fibroblast cadherin-2, PCDHGB4, CDH20, FIB2
Gene Name: PCDHGB4
Gene ID: 8641
Primary Accession: Q9UN71
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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