PCK1 Polyclonal Antibody

Background:
This gene is a main control point for the regulation of gluconeogenesis. The cytosolic enzyme encoded by this gene, along with GTP, catalyzes the formation of phosphoenolpyruvate from oxaloacetate, with the release of carbon dioxide and GDP. The expression of this gene can be regulated by insulin, glucocorticoids, glucagon, cAMP, and diet. Defects in this gene are a cause of cytosolic phosphoenolpyruvate carboxykinase deficiency. A mitochondrial isozyme of the encoded protein also has been characterized.

Research Area: Cancer, Cardiovascular, Metabolism, Signal Transduction

Synonyms:
cytosolic [GTP], GTP, PCK1, PCKGC, PEP carboxykinase, PEPCK-C, PEPCK1, PEPCKC, Phosphoenolpyruvate carboxykinase 1 (soluble), Phosphoenolpyruvate carboxykinase 1, Phosphoenolpyruvate carboxykinase, Phosphoenolpyruvate carboxykinase, cytosolic [GTP], Phosphoenolpyruvate carboxykinase, cytosolic, Phosphoenolpyruvate carboxylase, Phosphopyruvate carboxylase

Immunogen: Recombinant Rat Phosphoenolpyruvate carboxykinase, cytosolic [GTP] protein

Swissprot: P07379

Purification Method: Antigen Affinity Purification

Buffer: PBS with 0.05% Proclin300 and 50% glycerol, pH7.4.

Concentration: 1 mg/mL
Dilution: IHC 1:100-1:200

Storage:
Store at -20°C. Avoid freeze / thaw cycles.