PCK1 Polyclonal Antibody

Background:
This gene is a main control point for the regulation of gluconeogenesis. The cytosolic enzyme encoded by this gene, along with GTP, catalyzes the formation of phosphoenolpyruvate from oxaloacetate, with the release of carbon dioxide and GDP. The expression of this gene can be regulated by insulin, glucocorticoids, glucagon, cAMP, and diet. Defects in this gene are a cause of cytosolic phosphoenolpyruvate carboxykinase deficiency. A mitochondrial isozyme of the encoded protein also has been characterized.

Research Area: Cancer, Cardiovascular, Metabolism, Signal Transduction

Synonyms:
PCK1, PEPCK-C, PEPCK1, PEPCKC

Immunogen: A synthetic peptide of human PCK1 (NP_002582.3).

Swissprot: P35558
Gene ID: 5105

Calculated MW: 34 kDa/69 kDa
Observed MW: 69 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Concentration: 1 mg/mL
Dilution: "WB 1:1000-1:2000"

Storage:
Store at -20°C. Avoid freeze / thaw cycles.