PCLAF Polyclonal Antibody

Background:
PCNA-binding protein that acts as a regulator of DNA repair during DNA replication. Following DNA damage, the interaction with PCNA is disrupted, facilitating the interaction between monoubiquitinated PCNA and the translesion DNA synthesis DNA polymerase eta (POLH) at stalled replisomes, facilitating the bypass of replication-fork-blocking lesions. Also acts as a regulator of centrosome number.

Research Area: Cancer, Cell Biology, Metabolism

Synonyms:
L5, NS5 ATP9, NS5ATP9, OEATC 1, OEATC, OEATC-1, OEATC1, p15(PAF), p15PAF, PAF, PAF, PCNA associated factor, PCNA-associated factor,

Immunogen: Recombinant human KIAA0101 protein

Swissprot: Q15004

Calculated MW: 12 kDa
Observed MW: 12 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.05% Proclin300 and 50% glycerol, pH7.4.

Concentration: 2 mg/mL
Dilution: WB 1:500-1:1000,IHC 1:50-1:100

Storage:
Store at -20°C. Avoid freeze / thaw cycles.