PCNA [clone MD38R], anti-human, mouse, rat, monkey

Description: Proliferating cell nuclear antigen (PCNA) is a member of the DNA sliding clamp family of proteins that assist in DNA replication. Crystal structure data suggests that a PCNA homotrimer ring can encircle and slide along the DNA double helix. Multiple proteins involved in DNA replication, DNA repair, and cell cycle control bind to PCNA rather than directly associating with DNA, thus facilitating fast processing of DNA (reviewed in 3). PCNA protein expression is a well-accepted marker of proliferation.Localization: nucleusDilution: 200-400Positive Control: tonsilHIER: citrate pH6.0 or EDTA pH8.0Status: RUO