PCNA monoclonal, anti-human
€0.00
In stock
SKU
AC-AM8545b
Catalog Number: AC-AM8545b
Size: 50 µl, 200 µl
Isotype: mouse IgG1,k
Clone Name: 1655CT506.10.26
Applications: WB, FC, IHC-P
Datasheet
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Size: 50 µl, 200 µl
Isotype: mouse IgG1,k
Clone Name: 1655CT506.10.26
Applications: WB, FC, IHC-P
Datasheet
Request Information
Background:
Auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. Induces a robust stimulatory effect on the 3'- 5' exonuclease and 3'-phosphodiesterase, but not apurinic- apyrimidinic (AP) endonuclease, APEX2 activities. Has to be loaded onto DNA in order to be able to stimulate APEX2. Plays a key role in DNA damage response (DDR) by being conveniently positioned at the replication fork to coordinate DNA replication with DNA repair and DNA damage tolerance pathways. Acts as a loading platform to recruit DDR proteins that allow completion of DNA replication after DNA damage and promote postreplication repair: Monoubiquitinated PCNA leads to recruitment of translesion (TLS) polymerases, while 'Lys-63'-linked polyubiquitination of PCNA is involved in error-free pathway and employs recombination mechanisms to synthesize across the lesion.
Other Names:
Proliferating cell nuclear antigen, PCNA, Cyclin, PCNA
Target/Specificity:
This PCNA antibody is generated from a mouse immunized with a recombinant protein of human PCNA.
Antigen Type: Recombinant Protein
Gene Name: PCNA
Gene ID: 5111
Primary Accession: P12004
Other Accession: P61258
Format: Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS.
Auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. Induces a robust stimulatory effect on the 3'- 5' exonuclease and 3'-phosphodiesterase, but not apurinic- apyrimidinic (AP) endonuclease, APEX2 activities. Has to be loaded onto DNA in order to be able to stimulate APEX2. Plays a key role in DNA damage response (DDR) by being conveniently positioned at the replication fork to coordinate DNA replication with DNA repair and DNA damage tolerance pathways. Acts as a loading platform to recruit DDR proteins that allow completion of DNA replication after DNA damage and promote postreplication repair: Monoubiquitinated PCNA leads to recruitment of translesion (TLS) polymerases, while 'Lys-63'-linked polyubiquitination of PCNA is involved in error-free pathway and employs recombination mechanisms to synthesize across the lesion.
Other Names:
Proliferating cell nuclear antigen, PCNA, Cyclin, PCNA
Target/Specificity:
This PCNA antibody is generated from a mouse immunized with a recombinant protein of human PCNA.
Antigen Type: Recombinant Protein
Gene Name: PCNA
Gene ID: 5111
Primary Accession: P12004
Other Accession: P61258
Format: Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS.
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