PCP4 Polyclonal Antibody

Background:
PCP-4 (Purkinje cell protein 4), also known as PEP-19, is a calmodulin (CaM) regulatory protein that is highly expressed in neuronal cells. Through its IQ motif, PCP-4 mediates both the calcium-dependent binding properties of CaM and the rates of association and dissociation of calcium from the C-terminal domain of CaM. The IQ motif contains a serine residue which can be phosphorylated by all isoforms of protein kinase C (PKC). PCP-4 is implicated in uterine leiomyomas, as well as in neurodegenerative disorders such as Alzheimer’s disease and Huntington's disease. Additionally, overexpression of PCP-4 is thought to play a role in cerebellar hypoplasia, a key feature of Down syndrome.

Research Area: Neuroscience, Signal Transduction

Synonyms:
Brain specific antigen PCP 4, Brain specific polypeptide PEP 19, Brain specific polypeptide PEP19, Brain-specific antigen PCP-4, Brain-specific polypeptide PEP-19, OTTHUMP00000109191, Pcp4, PCP4, PEP19, Purkinje cell protein 4

Immunogen: Recombinant protein of human PCP4

Swissprot: P48539
Gene Accession: BC013791

Calculated MW: 7 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Concentration: 1 mg/mL
Dilution: WB 1:500-1:2000, IHC 1:100-1:300

Storage:
Store at -20°C. Avoid freeze / thaw cycles.

Alternative for product with catalog number:
sc-74816/sc-74817/sc-98549