PCSK9 polyclonal, anti-human antibody

Background:
Proprotein convertase subtilisin/kexin type 9 (PCSK9), is an enzyme which in humans is encoded by the PCSK9 gene. This gene encodes a proprotein convertase belonging to the proteinase K subfamily of the secretory subtilase family. This protein plays a major regulatory role in cholesterol homeostasis. PCSK9 binds to the epidermal growth factor-like repeat A (EGF-A) domain of the low-density lipoprotein receptor (LDLR), inducing LDLR degradation. PCSK9 may also have a role in the differentiation of cortical neurons. Mutations in this gene have been associated with a rare form of autosomal dominant familial hypercholesterolemia (HCHOLA3).

Other Names:
PCSK9, FH3, HCHOLA3, LDLCQ1, NARC1, PC9, FH3, NARC-1, HCHOLA3, PC9, Proprotein convertase 9, Subtilisin/kexin-like protease PC9, Hypercholesterolemia, autosomal dominant 3, Neural apoptosis-regulated convertase 1;

Primary Accession: Q8NBP7

Gene Name: PCSK9

Gene ID: 255738