PCSK9 polyclonal, anti-human

Quantity: 100 µg

Background:
Proprotein convertase subtilisin/kexin type 9, also known as PCSK9, is an enzyme that in humans is encoded by the PCSK9 gene. This gene encodes a proprotein convertase belonging to the proteinase K subfamily of the secretory subtilase family. By genomic sequence analysis, PCSK9 was mapped to chromosome 1p32. This gene is a crucial player in the regulation of plasma cholesterol homeostasis. It may prevent the recycling of LDLR from endosomes to the cell surface or direct it to lysosomes for degradation. PCSK9 can induce ubiquitination of LDLR leading to its subsequent degradation. This gene is involved in the disposal of non-acetylated intermediates of BACE1 in the early secretory pathway.

Description:
Rabbit IgG polyclonal antibody for Proprotein convertase subtilisin/kexin type 9 (PCSK9) detection. Tested with WB, IHC-P in Human.

Synonyms:
Convertase subtilisin/kexin type 9 preproprotein antibody, FH3 antibody, HCHOLA3 antibody, Hypercholesterolemia autosomal dominant 3 antibody, LDLCQ1 antibody, NARC 1 antibody, NARC-1 antibody, NARC1 antibody, Neural apoptosis regulated convertase 1 antibody, Neural apoptosis-regulated convertase 1 antibody, PC 9 antibody, PC9 antibody, PCSK 9 antibody, PCSK9 antibody, PCSK9_HUMAN antibody, Proprotein convertase 9 antibody, Proprotein convertase PC9 antibody, Proprotein convertase subtilisin/kexin type 9 antibody, PSEC0052 antibody, Subtilisin/kexin like protease PC9 antibody, Subtilisin/kexin-like protease PC9 antibody.

Isotype: Rabbit polyclonal IgG

Immunogen:
A synthetic peptide corresponding to a sequence at the C-terminus of human PCSK9(671-687aa AVTAVAICCRSRHLAQA).

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human

Applications: WB, IHC-P

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.