PCSK9 polyclonal, anti-human, mouse, rat
€388.00
In stock
SKU
BS71876
Background:
This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an autocatalytic processing event with its prosegment in the ER and is constitutively secreted as an inactive protease into the extracellular matrix and trans-Golgi network. It is expressed in liver, intestine and kidney tissues and escorts specific receptors for lysosomal degradation. It plays a role in cholesterol and fatty acid metabolism. Mutations in this gene have been associated with autosomal dominant familial hypercholesterolemia. Alternative splicing results in multiple transcript variants.
Alternative Name:
FH3, HCHOLA3, LDLCQ1, NARC-1, NARC1, PC9
Application Dilution: WB: 1:500 - 1:2000, IHC: 1:50 - 1:200
Specificity: PCSK9 polyclonal antibody detects endogenous levels of PCSK9 protein.
Immunogen:
A synthetic peptide of human PCSK9
MW: 72kDa
Swis Prot.: Q8NBP7
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an autocatalytic processing event with its prosegment in the ER and is constitutively secreted as an inactive protease into the extracellular matrix and trans-Golgi network. It is expressed in liver, intestine and kidney tissues and escorts specific receptors for lysosomal degradation. It plays a role in cholesterol and fatty acid metabolism. Mutations in this gene have been associated with autosomal dominant familial hypercholesterolemia. Alternative splicing results in multiple transcript variants.
Alternative Name:
FH3, HCHOLA3, LDLCQ1, NARC-1, NARC1, PC9
Application Dilution: WB: 1:500 - 1:2000, IHC: 1:50 - 1:200
Specificity: PCSK9 polyclonal antibody detects endogenous levels of PCSK9 protein.
Immunogen:
A synthetic peptide of human PCSK9
MW: 72kDa
Swis Prot.: Q8NBP7
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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