PCSK9 polyclonal, anti-human, mouse, rat

Background:
This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an autocatalytic processing event with its prosegment in the ER and is constitutively secreted as an inactive protease into the extracellular matrix and trans-Golgi network. It is expressed in liver, intestine and kidney tissues and escorts specific receptors for lysosomal degradation. It plays a role in cholesterol and fatty acid metabolism. Mutations in this gene have been associated with autosomal dominant familial hypercholesterolemia. Alternative splicing results in multiple transcript variants.

Synonyms: FH3, HCHOLA3, LDLCQ1, NARC-1, NARC1, PC9

Cellular Location: Cell surface Cytoplasm Endoplasmic reticulum Endosome Golgi apparatus Lysosome Secreted

Immunogen:
A synthetic peptide of human PCSK9

Gene Symbol: PCSK9

Gene ID: 255738

Swiss prot: Q8NBP7

Calculated MW: 74kDa

Recommended dilution:
WB 1:500-2000, IHC 1:50-200,

Purity:
Affinity purification

Storage Buffer:
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Storage:
Store at -20℃. Avoid freeze / thaw cycles.