PD1 / PDCD1 / CD279 (Programmed Cell Death 1) (clone PDCD1/922 ), anti-human

Background:
PDCD-1 (programmed cell death-1 protein), also designated CD279, is a type I transmembrane receptor and a member of the immunoglobin gene superfamily. It is expressed on activated T-cells, B-cells, and myeloid cells. Anti-PDCD-1 is a marker of angioimmunoblastic lymphoma and suggests a unique cell of origin for this neoplasm. Unlike CD10 and BCL6, PDCD-1 is expressed by few B-cells, so anti-PDCD-1 may be a more specific and useful diagnostic marker in angioimmunoblastic lymphoma. In addition, PDCD-1 expression provides evidence that angioimmunoblastic lymphoma is a neoplasm derived from germinal center-associated T-cells.

Other Names:
Programmed cell death protein 1, Protein PD-1, hPD-1, CD279, PDCD1, PD1

Gene Name: PDCD1 {ECO:0000303|PubMed:7851902, ECO:0000312|HGNC:HGNC:8760}
Gene ID: 5133
Primary Accession: Q15116
Other Accession: 5133, 158297