PDCD4 [clone EP102], anti-human

Description: Programmed cell death protein 4 (PDCD4) was initially identified as a differentially expressed protein during apoptosis. It acts as a tumor suppressor that inhibits tumor promoter-induced neoplastic transformation. It down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription. PDCD4 expression has been found in both normal and tumor cells. Reduced expression of PDCD4 is frequently observed in tumors. Loss of PDCD4 expression has been correlated with tumor progression and prognosis in cancers of the lung, ovary, pancreas and esophagus. Nuclear expression of PDCD4 was associated with a longer disease-free and overall survival rate of esophageal cancer.Localization: cytoplasm, nucleusDilution: 50-200Positive Control: breast caHIER: citrate pH6.0Status: RUO