PDCD6 Polyclonal Antibody

Background:
This gene encodes a calcium-binding protein belonging to the penta-EF-hand protein family. Calcium binding is important for homodimerization and for conformational changes required for binding to other protein partners. This gene product participates in T cell receptor-, Fas-, and glucocorticoid-induced programmed cell death. In mice deficient for this gene product, however, apoptosis was not blocked suggesting this gene product is functionally redundant. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is also located on the short arm of chromosome 5.

Research Area: Cancer, Cell Biology, Signal Transduction

Synonyms:
PDCD6, ALG-2, ALG2, PEF1B

Immunogen: Recombinant fusion protein of human PDCD6 (NP_037364.1).

Swissprot: O75340
Gene ID: 10016

Calculated MW: 7 kDa/21 kDa
Observed MW: 16 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Concentration: 1 mg/mL
Dilution: "WB 1:500-1:2000 IHC 1:50-1:200 IF 1:50-1:100"

Storage:
Store at -20°C. Avoid freeze / thaw cycles.