PDE11A polyclonal, anti-human

Background:
The 3',5'-cyclic nucleotides cAMP and cGMP function as second messengers in a wide variety of signal transduction pathways. 3',5'-cyclic nucleotide phosphodiesterases (PDEs) catalyze the hydrolysis of cAMP and cGMP to the corresponding 5'-monophosphates and provide a mechanism to downregulate cAMP and cGMP signaling. This gene encodes a member of the PDE protein superfamily. Mutations in this gene are a cause of Cushing disease and adrenocortical hyperplasia. Multiple transcript variants encoding different isoforms have been found for this gene.

Other Names:
Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A, 3.1.4.17, 3.1.4.35, cAMP and cGMP phosphodiesterase 11A, PDE11A

Antigen Types:
Synthetic Peptide

Gene Name:
PDE11A {ECO:0000303|PubMed:10906126, ECO:0000312|HGNC:HGNC:8773}
Gene ID:
50940
Primary Accession: Q9HCR9
Other Accession: NP_001070664;50940;241489 (mouse); 140928 (rat);