PDE4C polyclonal, anti-human, mouse, rat
€305.00
In stock
SKU
BS5844
Background:
Phosphodiesterases (PDE) hydrolyze cAMP to 5’AMP and thus play a critical role in the regulation of intracellular cAMP. Division of the PDE superfamily by sequence homology and enzymatic properties yields 11 PDE families. A unique upstream conserved region (UCR) characterizes the PDE4 family. Four separate genes (A-D) encode the PDE4 enzymes, and alternative splicing generates short or long isoforms of each gene. Long PDE4 isoforms contain both UCR1 and UCR2 while short PDE4 isoforms possess only UCR2. Both UCR domains are necessary for dimerization of PDE4 isoforms. The human PDE4C gene maps to chromosome 19p13.1. The splice variants include isoforms PDE4C1-7.
Alternative Name:
cAMP-specific 3',5'-cyclic phosphodiesterase 4C, DPDE1, PDE21, DPDE1
Application Dilution: WB: 1:500~1:1000, ICC: 1:50~1:200
Specificity: PDE4C polyclonal antibody detects endogenous levels of PDE4C protein.
Immunogen:
Synthetic peptide, corresponding to amino acids 333-378 of Human PDE4C.
MW: ~ 80 kDa
Swis Prot.: Q08493
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
Phosphodiesterases (PDE) hydrolyze cAMP to 5’AMP and thus play a critical role in the regulation of intracellular cAMP. Division of the PDE superfamily by sequence homology and enzymatic properties yields 11 PDE families. A unique upstream conserved region (UCR) characterizes the PDE4 family. Four separate genes (A-D) encode the PDE4 enzymes, and alternative splicing generates short or long isoforms of each gene. Long PDE4 isoforms contain both UCR1 and UCR2 while short PDE4 isoforms possess only UCR2. Both UCR domains are necessary for dimerization of PDE4 isoforms. The human PDE4C gene maps to chromosome 19p13.1. The splice variants include isoforms PDE4C1-7.
Alternative Name:
cAMP-specific 3',5'-cyclic phosphodiesterase 4C, DPDE1, PDE21, DPDE1
Application Dilution: WB: 1:500~1:1000, ICC: 1:50~1:200
Specificity: PDE4C polyclonal antibody detects endogenous levels of PDE4C protein.
Immunogen:
Synthetic peptide, corresponding to amino acids 333-378 of Human PDE4C.
MW: ~ 80 kDa
Swis Prot.: Q08493
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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