PDE6A Antibody (Center) Blocking Peptide
€363.00
In stock
SKU
AC-BP13220c
Background:
This gene encodes the cyclic-GMP (cGMP)-specificphosphodiesterase 6A alpha subunit, expressed in cells of theretinal rod outer segment. The phosphodiesterase 6 holoenzyme is aheterotrimer composed of an alpha, beta, and two gamma subunits.cGMP is an important regulator of rod cell membrane current, andits dynamic concentration is established by phosphodiesterase 6AcGMP hydrolysis and guanylate cyclase cGMP synthesis. The proteinis a subunit of a key phototransduction enzyme and participates inprocesses of transmission and amplification of the visual signal.Mutations in this gene have been identified as one cause ofautosomal recessive retinitis pigmentosa.
Other Names:
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha, GMP-PDE alpha, PDE V-B1, PDE6A, PDEA
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP13220c was selected from the Center region of PDE6A. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: PDE6A (HGNC:8785)
Gene ID: 5145
Primary Accession: P16499
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
This gene encodes the cyclic-GMP (cGMP)-specificphosphodiesterase 6A alpha subunit, expressed in cells of theretinal rod outer segment. The phosphodiesterase 6 holoenzyme is aheterotrimer composed of an alpha, beta, and two gamma subunits.cGMP is an important regulator of rod cell membrane current, andits dynamic concentration is established by phosphodiesterase 6AcGMP hydrolysis and guanylate cyclase cGMP synthesis. The proteinis a subunit of a key phototransduction enzyme and participates inprocesses of transmission and amplification of the visual signal.Mutations in this gene have been identified as one cause ofautosomal recessive retinitis pigmentosa.
Other Names:
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha, GMP-PDE alpha, PDE V-B1, PDE6A, PDEA
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP13220c was selected from the Center region of PDE6A. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: PDE6A (HGNC:8785)
Gene ID: 5145
Primary Accession: P16499
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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