PDE6A polyclonal (Center), anti-human
€0.00
In stock
SKU
AC-AP13220C
Catalog Number: AC-AP13220C
Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB33012
Applications: WB
Datasheet
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Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB33012
Applications: WB
Datasheet
Request Information
Background:
This gene encodes the cyclic-GMP (cGMP)-specific phosphodiesterase 6A alpha subunit, expressed in cells of the retinal rod outer segment. The phosphodiesterase 6 holoenzyme is a heterotrimer composed of an alpha, beta, and two gamma subunits. cGMP is an important regulator of rod cell membrane current, and its dynamic concentration is established by phosphodiesterase 6A cGMP hydrolysis and guanylate cyclase cGMP synthesis. The protein is a subunit of a key phototransduction enzyme and participates in processes of transmission and amplification of the visual signal. Mutations in this gene have been identified as one cause of autosomal recessive retinitis pigmentosa.
Other Names:
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha, GMP-PDE alpha, PDE V-B1, PDE6A, PDEA
Target/Specificity:
This PDE6A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 308-336 amino acids from the Central region of human PDE6A.
Antigen Region:
308-336
Antigen Type: Synthetic Peptide
Gene Name: PDE6A (HGNC:8785)
Gene ID: 5145
Primary Accession: P16499
NCBI Accession: NP_000431.2
Other Accession: P27664; P11541; NP_000431.2
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
This gene encodes the cyclic-GMP (cGMP)-specific phosphodiesterase 6A alpha subunit, expressed in cells of the retinal rod outer segment. The phosphodiesterase 6 holoenzyme is a heterotrimer composed of an alpha, beta, and two gamma subunits. cGMP is an important regulator of rod cell membrane current, and its dynamic concentration is established by phosphodiesterase 6A cGMP hydrolysis and guanylate cyclase cGMP synthesis. The protein is a subunit of a key phototransduction enzyme and participates in processes of transmission and amplification of the visual signal. Mutations in this gene have been identified as one cause of autosomal recessive retinitis pigmentosa.
Other Names:
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha, GMP-PDE alpha, PDE V-B1, PDE6A, PDEA
Target/Specificity:
This PDE6A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 308-336 amino acids from the Central region of human PDE6A.
Antigen Region:
308-336
Antigen Type: Synthetic Peptide
Gene Name: PDE6A (HGNC:8785)
Gene ID: 5145
Primary Accession: P16499
NCBI Accession: NP_000431.2
Other Accession: P27664; P11541; NP_000431.2
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
| Is Featured? | No |
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