PDE6B polyclonal, anti-human, mouse, rat
€388.00
In stock
SKU
BS8599
Background:
Photon absorption triggers a signaling cascade in rod photoreceptors that activates cGMP phosphodiesterase (PDE), resulting in the rapid hydrolysis of cGMP, closure of cGMP-gated cation channels, and hyperpolarization of the cell. PDE is a peripheral membrane heterotrimeric enzyme made up of alpha, beta, and gamma subunits. This gene encodes the beta subunit. Mutations in this gene result in retinitis pigmentosa and autosomal dominant congenital stationary night blindness. Multiple transcript variants encoding different isoforms have been found for this gene.
Alternative Name:
Rod cGMP-specific 3', 5'-cyclic phosphodiesterase subunit beta, GMP-PDE beta, PDE6B, PDEB
Application Dilution: WB: 1:500 - 1:2000
Specificity: PDE6B polyclonal antibody detects endogenous levels of PDE6B protein.
Immunogen:
Recombinant full length Human PDE6B.
MW: ~ 98kDa
Swis Prot.: P35913
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
Photon absorption triggers a signaling cascade in rod photoreceptors that activates cGMP phosphodiesterase (PDE), resulting in the rapid hydrolysis of cGMP, closure of cGMP-gated cation channels, and hyperpolarization of the cell. PDE is a peripheral membrane heterotrimeric enzyme made up of alpha, beta, and gamma subunits. This gene encodes the beta subunit. Mutations in this gene result in retinitis pigmentosa and autosomal dominant congenital stationary night blindness. Multiple transcript variants encoding different isoforms have been found for this gene.
Alternative Name:
Rod cGMP-specific 3', 5'-cyclic phosphodiesterase subunit beta, GMP-PDE beta, PDE6B, PDEB
Application Dilution: WB: 1:500 - 1:2000
Specificity: PDE6B polyclonal antibody detects endogenous levels of PDE6B protein.
Immunogen:
Recombinant full length Human PDE6B.
MW: ~ 98kDa
Swis Prot.: P35913
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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