PDE6B polyclonal, anti-human, mouse, rat

Background:
Photon absorption triggers a signaling cascade in rod photoreceptors that activates cGMP phosphodiesterase (PDE), resulting in the rapid hydrolysis of cGMP, closure of cGMP-gated cation channels, and hyperpolarization of the cell. PDE is a peripheral membrane heterotrimeric enzyme made up of alpha, beta, and gamma subunits. This gene encodes the beta subunit. Mutations in this gene result in retinitis pigmentosa and autosomal dominant congenital stationary night blindness. Multiple transcript variants encoding different isoforms have been found for this gene.

Synonyms: CSNB3, CSNBAD2, PDEB, RP40, rd1

Cellular Location: Lipid-anchor Membrane

Immunogen:
Recombinant protein of human PDE6B

Gene Symbol: PDE6B

Gene ID: 5158

Swiss prot: P35913

Calculated MW: 98kDa

Recommended dilution:
WB 1:500-2000

Purity:
Affinity purification

Storage Buffer:
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Storage:
Store at -20℃. Avoid freeze / thaw cycles.