PDF Antibody (Center) Blocking Peptide
€363.00
In stock
SKU
AC-BP19023c
Background:
Protein synthesis proceeds after formylation of methionineby methionyl-tRNA formyl transferase (FMT) and transfer of thecharged initiator f-met tRNA to the ribosome. In eubacteria andeukaryotic organelles the product of this gene, peptide deformylase(PDF), removes the formyl group from the initiating methionine ofnascent peptides. In eubacteria, deformylation of nascent peptidesis required for subsequent cleavage of initiating methionines bymethionine aminopeptidase. The discovery that a natural inhibitorof PDF, actinonin, acts as an antimicrobial agent in some bacteriahas spurred intensive research into the design ofbacterial-specific PDF inhibitors. In human cells, onlymitochondrial proteins have N-formylation of initiatingmethionines. Protein inhibitors of PDF or siRNAs of PDF block thegrowth of cancer cell lines but have no effect on normal cellgrowth. In humans, PDF function may therefore be restricted torapidly growing cells.
Other Names:
Peptide deformylase, mitochondrial, Polypeptide deformylase, PDF, PDF1A
Gene Name: PDF {ECO:0000303|PubMed:19236878}
Gene ID: 64146
Primary Accession: Q9HBH1
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
Protein synthesis proceeds after formylation of methionineby methionyl-tRNA formyl transferase (FMT) and transfer of thecharged initiator f-met tRNA to the ribosome. In eubacteria andeukaryotic organelles the product of this gene, peptide deformylase(PDF), removes the formyl group from the initiating methionine ofnascent peptides. In eubacteria, deformylation of nascent peptidesis required for subsequent cleavage of initiating methionines bymethionine aminopeptidase. The discovery that a natural inhibitorof PDF, actinonin, acts as an antimicrobial agent in some bacteriahas spurred intensive research into the design ofbacterial-specific PDF inhibitors. In human cells, onlymitochondrial proteins have N-formylation of initiatingmethionines. Protein inhibitors of PDF or siRNAs of PDF block thegrowth of cancer cell lines but have no effect on normal cellgrowth. In humans, PDF function may therefore be restricted torapidly growing cells.
Other Names:
Peptide deformylase, mitochondrial, Polypeptide deformylase, PDF, PDF1A
Gene Name: PDF {ECO:0000303|PubMed:19236878}
Gene ID: 64146
Primary Accession: Q9HBH1
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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