PDF polyclonal (Center), anti-human
€0.00
In stock
SKU
AC-AP19023c
Catalog Number: AC-AP19023c
Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB39612
Applications: WB
Datasheet
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Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB39612
Applications: WB
Datasheet
Request Information
Background:
Protein synthesis proceeds after formylation of methionineby methionyl-tRNA formyl transferase (FMT) and transfer of thecharged initiator f-met tRNA to the ribosome. In eubacteria andeukaryotic organelles the product of this gene, peptide deformylase(PDF), removes the formyl group from the initiating methionine ofnascent peptides. In eubacteria, deformylation of nascent peptidesis required for subsequent cleavage of initiating methionines bymethionine aminopeptidase. The discovery that a natural inhibitorof PDF, actinonin, acts as an antimicrobial agent in some bacteriahas spurred intensive research into the design ofbacterial-specific PDF inhibitors. In human cells, onlymitochondrial proteins have N-formylation of initiatingmethionines. Protein inhibitors of PDF or siRNAs of PDF block thegrowth of cancer cell lines but have no effect on normal cellgrowth. In humans, PDF function may therefore be restricted torapidly growing cells.
Other Names:
Peptide deformylase, mitochondrial, Polypeptide deformylase, PDF, PDF1A
Target/Specificity:
This PDF antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 125-151 amino acids from the Central region of human PDF.
Antigen Region:
125-151
Antigen Type: Synthetic Peptide
Gene Name: PDF {ECO:0000303|PubMed:19236878}
Gene ID: 64146
Primary Accession: Q9HBH1
NCBI Accession: NP_071736.1
Other Accession: NP_071736.1
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Protein synthesis proceeds after formylation of methionineby methionyl-tRNA formyl transferase (FMT) and transfer of thecharged initiator f-met tRNA to the ribosome. In eubacteria andeukaryotic organelles the product of this gene, peptide deformylase(PDF), removes the formyl group from the initiating methionine ofnascent peptides. In eubacteria, deformylation of nascent peptidesis required for subsequent cleavage of initiating methionines bymethionine aminopeptidase. The discovery that a natural inhibitorof PDF, actinonin, acts as an antimicrobial agent in some bacteriahas spurred intensive research into the design ofbacterial-specific PDF inhibitors. In human cells, onlymitochondrial proteins have N-formylation of initiatingmethionines. Protein inhibitors of PDF or siRNAs of PDF block thegrowth of cancer cell lines but have no effect on normal cellgrowth. In humans, PDF function may therefore be restricted torapidly growing cells.
Other Names:
Peptide deformylase, mitochondrial, Polypeptide deformylase, PDF, PDF1A
Target/Specificity:
This PDF antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 125-151 amino acids from the Central region of human PDF.
Antigen Region:
125-151
Antigen Type: Synthetic Peptide
Gene Name: PDF {ECO:0000303|PubMed:19236878}
Gene ID: 64146
Primary Accession: Q9HBH1
NCBI Accession: NP_071736.1
Other Accession: NP_071736.1
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
| Is Featured? | No |
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