PDGFB polyclonal (C-term), anti-human

Background:
PDGFB is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a motif of eight cysteines. This gene product can exist either as a homodimer or as a heterodimer with the platelet-derived growth factor alpha polypeptide, where the dimers are connected by disulfide bonds. Mutations in this gene are associated with meningioma. Reciprocal translocations between chromosomes 22 and 7, at sites where this gene and that for COL1A1 are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans resulting from unregulated expression of growth factor.

Other Names:
Platelet-derived growth factor subunit B, PDGF subunit B, PDGF-2, Platelet-derived growth factor B chain, Platelet-derived growth factor beta polypeptide, Proto-oncogene c-Sis, Becaplermin, PDGFB, PDGF2, SIS

Target/Specificity:
This PDGFB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 212-241 amino acids from the C-terminal region of human PDGFB.

Antigen Region:
212-241

Antigen Type: Synthetic Peptide

Gene Name: PDGFB
Gene ID: 5155
Primary Accession: P01127
NCBI Accession: NP_002599.1;NP_148937.1
Other Accession: NP_148937
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.