PDGFRB Polyclonal Antibody

Background:
This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. This gene is flanked on chromosome 5 by the genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor; all three genes may be implicated in the 5-q syndrome. A translocation between chromosomes 5 and 12, that fuses this gene to that of the translocation, ETV6, leukemia gene, results in chronic myeloproliferative disorder with eosinophilia.

Research Area: Cancer, Cardiovascular, Signal Transduction

Synonyms:
Beta platelet derived growth factor receptor, Beta-type platelet-derived growth factor receptor, CD 140B, CD140 antigen-like family member B, CD140b, CD140b antigen, IBGC4, IMF1, JTK12, OTTHUMP00000160528, PDGF R beta, PDGF-R-beta, PDGFR 1, PDGFR, PDGFR beta, PDGFR1, PDGFRB, PGFRB, Platelet derived growth factor receptor 1, Platelet derived growth factor receptor beta, Platelet derived growth factor receptor beta polypeptide

Immunogen: Synthesized peptide derived from human PDGFR-β around the non-phosphorylation site of Tyr751.

Swissprot: P09619

Calculated MW: 124 kDa
Observed MW: 124 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4

Concentration: 1 mg/mL
Dilution: WB 1:500-1:2000, IHC 1:100-1:300, IF 1:200-1:1000, ELISA 1:40000

Storage:
Store at -20°C. Avoid freeze / thaw cycles.

Alternative for product with catalog number:
sc-1627/sc-432/sc-339

Citation(s):
https://www.liebertpub.com/doi/abs/10.1089/jir.2018.0113