PDI polyclonal, anti-human, mouse, rat

Background:
Oxidoreductase-protein disulfide isomerase (PDI) is a homodimer consisting of subunits that catalyzes thiol-disulfide exchange, mediates folding of newly synthesized proteins and functions as a molecular chaperone. PDI localizes to the lumen of the endoplasmic reticulum (ER), where in conjunction with folding-helper proteins, such as immunoglobulin heavy chain binding protein (BiP), mediates tertiary and quaternary protein-processing. Cell surface PDI induces sulfhydryl-mediated conformational changes in integrin-mediated adhesion receptor-ligand interactions, thereby regulating integrin responses and cell adhesion. Additionally, PDI functions as a subunit of two more complex enzyme systems: the prolyl-4-hydroxylase and the triacylglycerol transfer proteins.

Alternative Name:
PDIp, Pdia2, Pancreas specific protein disulfide isomerase, Pancreas-specific protein disulfide isomerase, Pancreatic protein disulfide isomerase, PDA2, PDI, PDIA2, PDIA2, PDIp, PDIR, Protein disulfide isomerase A2, Protein disulfide isomerase, Protein disulfide isomerase associated 2, Protein disulfide isomerase family A member 2, Protein disulfide isomerase pancreatic, Protein disulfide-isomerase A2, Rho GDP dissociation inhibitor gamma,

Application Dilution:
WB:1:1,000-1:2,000
FC:1:50-1:100

Specificity: PDI polyclonal antibody detects endogenous levels of PDI protein.

Immunogen:
recombinant protein

MW: 58 kDa

Swiss-Prot: P07237(Human) Q13087(Human) D3Z6P0(Mouse) Unigene:65154(Rat)

Purification & Purity:
ProA affinity purified

Format:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Storage:
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

For research use only, not for use in diagnostic procedure.