PDIA1 monoclonal, anti-human
€0.00
In stock
SKU
AC-AM8515b
Catalog Number: AC-AM8515b
Size: 50 µl, 200 µl
Isotype: mouse IgG1,k
Clone Name: 1530CT836.11.53
Applications: WB
Datasheet
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Size: 50 µl, 200 µl
Isotype: mouse IgG1,k
Clone Name: 1530CT836.11.53
Applications: WB
Datasheet
Request Information
Background:
This multifunctional protein catalyzes the formation, breakage and rearrangement of disulfide bonds. At the cell surface, seems to act as a reductase that cleaves disulfide bonds of proteins attached to the cell. May therefore cause structural modifications of exofacial proteins. Inside the cell, seems to form/rearrange disulfide bonds of nascent proteins. At high concentrations, functions as a chaperone that inhibits aggregation of misfolded proteins. At low concentrations, facilitates aggregation (anti-chaperone activity). May be involved with other chaperones in the structural modification of the TG precursor in hormone biogenesis. Also acts a structural subunit of various enzymes such as prolyl 4-hydroxylase and microsomal triacylglycerol transfer protein MTTP.
Other Names:
Protein disulfide-isomerase, PDI, Cellular thyroid hormone-binding protein, Prolyl 4-hydroxylase subunit beta, p55, P4HB, ERBA2L, PDI, PDIA1, PO4DB
Target/Specificity:
This PDIA1 antibody is generated from a mouse immunized with a recombinant protein of human PDIA1.
Antigen Type: Recombinant Protein
Gene Name: P4HB
Gene ID: 5034
Primary Accession: P07237
Format: Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS.
This multifunctional protein catalyzes the formation, breakage and rearrangement of disulfide bonds. At the cell surface, seems to act as a reductase that cleaves disulfide bonds of proteins attached to the cell. May therefore cause structural modifications of exofacial proteins. Inside the cell, seems to form/rearrange disulfide bonds of nascent proteins. At high concentrations, functions as a chaperone that inhibits aggregation of misfolded proteins. At low concentrations, facilitates aggregation (anti-chaperone activity). May be involved with other chaperones in the structural modification of the TG precursor in hormone biogenesis. Also acts a structural subunit of various enzymes such as prolyl 4-hydroxylase and microsomal triacylglycerol transfer protein MTTP.
Other Names:
Protein disulfide-isomerase, PDI, Cellular thyroid hormone-binding protein, Prolyl 4-hydroxylase subunit beta, p55, P4HB, ERBA2L, PDI, PDIA1, PO4DB
Target/Specificity:
This PDIA1 antibody is generated from a mouse immunized with a recombinant protein of human PDIA1.
Antigen Type: Recombinant Protein
Gene Name: P4HB
Gene ID: 5034
Primary Accession: P07237
Format: Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS.
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