PDK3 monoclonal (Ascites), anti-human
€470.00
In stock
SKU
AC-AM2038a
Catalog Number: AC-AM2038a
Size: 100 µl
Isotype: mouse IgG2b
Clone Name: 431CT6.1
Applications: WB
Datasheet
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Size: 100 µl
Isotype: mouse IgG2b
Clone Name: 431CT6.1
Applications: WB
Datasheet
Request Information
Background:
The pyruvate dehydrogenase (PDH) complex is a nuclear-encoded mitochondrial multienzyme complex that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It provides the primary link between glycolysis and the tricarboxylic acid (TCA) cycle, and thus is one of the major enzymes responsible for the regulation of glucose metabolism. The enzymatic activity of PDH is regulated by a phosphorylation/dephosphorylation cycle, and phosphorylation results in inactivation of PDH. The protein encoded by this gene is one of the three pyruvate dehydrogenase kinases that inhibits the PDH complex by phosphorylation of the E1 alpha subunit. This gene is predominantly expressed in the heart and skeletal muscles. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Other Names:
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial, Pyruvate dehydrogenase kinase isoform 3, PDK3, PDHK3
Target/Specificity:
Purified His-tagged PDK3 protein(Fragment) was used to produced this monoclonal antibody.
Antigen Type: Recombinant Protein
Gene Name: PDK3
Gene ID: 5165
Primary Accession: Q15120
NCBI Accession: NP_001135858.1;NP_005382.1
Other Accession: NP_005382.1
Format: Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.
The pyruvate dehydrogenase (PDH) complex is a nuclear-encoded mitochondrial multienzyme complex that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It provides the primary link between glycolysis and the tricarboxylic acid (TCA) cycle, and thus is one of the major enzymes responsible for the regulation of glucose metabolism. The enzymatic activity of PDH is regulated by a phosphorylation/dephosphorylation cycle, and phosphorylation results in inactivation of PDH. The protein encoded by this gene is one of the three pyruvate dehydrogenase kinases that inhibits the PDH complex by phosphorylation of the E1 alpha subunit. This gene is predominantly expressed in the heart and skeletal muscles. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Other Names:
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial, Pyruvate dehydrogenase kinase isoform 3, PDK3, PDHK3
Target/Specificity:
Purified His-tagged PDK3 protein(Fragment) was used to produced this monoclonal antibody.
Antigen Type: Recombinant Protein
Gene Name: PDK3
Gene ID: 5165
Primary Accession: Q15120
NCBI Accession: NP_001135858.1;NP_005382.1
Other Accession: NP_005382.1
Format: Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.
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