PDL-2 polyclonal, anti-human, mouse, rat

Protein Family: Cell Adhesion Molecules, Cellular Antigens

Pathway and Disease: Immune System, Signaling Molecules and Interaction

Description:
Cell-mediated immune responses are initiated by T lymphocytes that are themselves stimulated by co gnate peptides bound to MHC molecules on antigen-presenting cells (APC). T-cell activation is generally self-limited as activated T cells express receptors such as PD-1 (also known as PDCD-1) that mediate inhibitory signals from the APC. PD-1 can bind two different but related ligands, PDL-1 and PDL-2, both of which are thought act as a negative regulator of T cell activation. However, it has been suggested that PDL-2 can act to stimulate an immunogenic response through and alternative receptor from PD-1. At least three isoforms of PDL-2 are known to exist; this antibody is specific to the largest isoform. PDL-2 antibody has no cross-reactivity to PDL-2.

Alternate Names: PDL-2, Programmed cell death 1 ligand 2, Programmed death ligand 2, PD-L2, B7DC, PDCD1LG2, PD-1 ligand 2, PDCD1 ligand 2, Butyrophilin B7-DC, B7-DC, CD273, B7DC, PDCD1L2, PDL2

Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500; IHC: 1:100-1:500; IF: 1:50-1:200

Accession No.: NP_079515

Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the center region of human PDL-2.

Format: Each vial contains 0.1 ml IgG (1 mg/ml) in PBS pH 7.4 with 0.02% sodium azide. Antibody was purified by immunogen affinity chromatography.

Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.