PDX-1 polyclonal, anti-human, mouse, rat, pig, chicken

Protein Family: Transcription Factors

Pathway and Disease: Metabolic Disorders, Transcription

Description:
Pancreas/duodenum homeobox protein 1 (PDX-1) activates insulin, somatostatin, glucokinase, islet amyloid polypeptide and glucose transporter type 2 gene transcription. PDX-1 is particularly involved in glucose-dependent regulation of insulin gene transcription. PDX-1 binds preferentially the DNA motif 5'-[CT]TAAT[TG]-3'. During development, PDX-1 specifies the early pancreatic epithelium, permitting its proliferation, branching and subsequent differentiation. At the adult stage, PDX-1 is required for maintaining the hormone-producing phenotype of the beta-cell.

Alternate Names: PDX-1, Pancreatic and duodenal homeobox 1, Pancreas/duodenum homeobox 1, Insulin promoter factor 1, IPF-1, Islet/duodenum homeobox-1, IDX-1, Somatostatin-transactivating factor 1, STF-1, Insulin upstream factor 1, IUF-1, Glucose-sensitive factor, GSF, PDX1, IPF1

Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500; IHC: 1:100-1:500

Accession No.: P52945

Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of mouse PDX-1.

Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 25% glycerol, 0.1 mg/ml BSA with 0.09% sodium azide. Antibody was purified by Protein-A affinity chromatography.

Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.