PDX1 [clone EP139], anti-human

Description: PDX1 (Pancreatic and duodenal homeobox 1), also known as insulin promoter factor 1, is a transcription factor necessary for pancreatic development and β-cell maturation. Mutations in the PDX-1 gene have been shown to cause pancreatic agenesis, maturity-onset diabetes of the young, and type II diabetes. PDX1 is initially expressed in the gut region of the embryo and selectively expressed in adult endocrine glands such as pancreatic beta-cells, Brunner’s glands of the duodenum and pyloric endocrine cells of the stomach. In pancreas, PDX1 may be observed in a subset of exocrine and duct cells. Increased expression of PDX1 has been reported in tumors of the pancreas, colon and prostate, indicating that PDX1 may serve as a biomarker in patients with these malignancies.Localization: nucleusDilution: 50-200Positive Control: pancreas, duodenumHIER: citrate pH6.0 or EDTA pH8.0Status: RUO