PDX1 Polyclonal Antibody

Background:
The protein encoded by this gene is a transcriptional activator of several genes, including insulin, somatostatin, glucokinase, islet amyloid polypeptide, and glucose transporter type 2. The encoded nuclear protein is involved in the early development of the pancreas and plays a major role in glucose-dependent regulation of insulin gene expression. Defects in this gene are a cause of pancreatic agenesis, which can lead to early-onset insulin-dependent diabetes mellitus (NIDDM), as well as maturity onset diabetes of the young type 4 (MODY4).

Research Area: Cancer, Cardiovascular, Epigenetics and Nuclear Signaling, Metabolism, Developmental Biology, Signal Transduction, Stem Cells

Synonyms:
PDX1, GSF, IDX-1, IPF1, IUF1, MODY4, PAGEN1, PDX-1, STF-1

Immunogen: A synthetic peptide of human PDX1 (NP_000200.1).

Swissprot: P52945
Gene ID: 3651

Calculated MW: 30 kDa
Observed MW: 39 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Concentration: 1 mg/mL
Dilution: "WB 1:500-1:1000"

Storage:
Store at -20°C. Avoid freeze / thaw cycles.