PDZ-RhoGEF polyclonal antibody, anti-human, mouse, rat

Background:
Periphilin 1 encoded by PPHLN1 is one of the several proteins that become sequentially incorporated into the cornified cell envelope during the terminal differentiation of keratinocyte at the outer layers of epidermis. Periphilin 1 interacts with periplakin, which is known as a precursor of the cornified cell envelope. The cellular localization pattern and insolubility of periphilin 1 suggest that it may play a role in epithelial differentiation and contribute to epidermal integrity and barrier formation. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed.

Research Area: Signal Transduction

Synonyms: ARHGEF11, KIAA0380, Rho guanine nucleotide exchange factor 11, PDZ-RhoGEF

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

Storage:
-20°C for 1 year