PDZK1 Polyclonal Antibody

Background:
This gene encodes a PDZ domain-containing scaffolding protein. PDZ domain-containing molecules bind to and mediate the subcellular localization of target proteins. The encoded protein mediates the localization of cell surface proteins and plays a critical role in cholesterol metabolism by regulating the HDL receptor, scavenger receptor class B type 1. Single nucleotide polymorphisms in this gene may be associated with metabolic syndrome, and overexpression of this gene may play a role in drug resistance of multiple myeloma. Pseudogenes of this gene are located on the long arm of chromosome 1. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Research Area: Cancer, Metabolism, Signal Transduction

Synonyms:
PDZK1, CAP70, CLAMP, NHERF-3, NHERF3, PDZD1

Immunogen: Recombinant fusion protein of human PDZK1 (NP_001188254.1).

Swissprot: Q5T2W1
Gene ID: 5174

Calculated MW: 44 kDa/57 kDa
Observed MW: 67 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Concentration: 1 mg/mL
Dilution: "WB 1:500-1:2000"

Storage:
Store at -20°C. Avoid freeze / thaw cycles.