PEN2 polyclonal, anti-human, mouse, rat

Background:
Four proteins comprise the gamma-secretase complex: presenilin, nicastrin, aph-1, and PEN-2. Together, these proteins mediate cell surface signaling pathways for a variety of type I membrane proteins, notably amyloid-beta precursor protein, a protein implicated in the development of Alzheimer's disease, via intramembrane proteolysis. The proteins assemble into a proteolytically active complex in the golgi/trans-golgi network (TGN) compartments. Assembly leads to autocleavage of presenilin into two subunits to create the active site of gamma-secretase, an important step in understanding the mechanisms involved in the etiology and possible treatment of Alzheimer's disease.

Alternative Name:
PSENEN, PEN2, MDS033, Gamma secretase subunit PEN 2, Gamma Secretase Subunit PEN2, Gamma-secretase subunit PEN-2, Hematopoietic stem/progenitor cells protein MDS033, MDS033, MSTP064, PEN 2, PEN2, Presenilin Enhancer 2, Presenilin enhancer 2 homolog, Presenilin enhancer protein 2, PSEN2, psenen,

Application Dilution:
WB:1:500-1:2,000
IHC:1:50-1:200
ICC:1:50-1:200
FC:1:50-1:100

Specificity: PEN2 polyclonal antibody detects endogenous levels of PEN2 protein.

Immunogen:
Synthetic peptide corresponding to C-terminal human PEN2.

MW: 12 kDa

Swiss-Prot: Q9NZ42(Human) Q9CQR7(Mouse) O88777(Rat)

Purification & Purity:
ProA affinity purified

Format:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Storage:
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.

For research use only, not for use in diagnostic procedure.