PEN2 polyclonal, anti-human, mouse, rat

Background:
Four proteins comprise the gamma-secretase complex: presenilin, nicastrin, aph-1, and PEN-2. Together, these proteins mediate cell surface signaling pathways for a variety of type I membrane proteins, notably amyloid-beta precursor protein, a protein implicated in the development of Alzheimer's disease, via intramembrane proteolysis. The proteins assemble into a proteolytically active complex in the golgi/trans-golgi network (TGN) compartments. Assembly leads to autocleavage of presenilin into two subunits to create the active site of gamma-secretase, an important step in understanding the mechanisms involved in the etiology and possible treatment of Alzheimer's disease.

Alternative Name:
Gamma-secretase subunit PEN-2, Presenilin enhancer protein 2, PSENEN, PEN2, MDS033

Application Dilution: WB: 1:500-1:2000, IHC: 1:50-1:200, ICC: 1:50-1:200, FC: 1:50-1:100

Specificity: This antibody detects endogenous levels of PEN2 and does not cross-react with related proteins.

Immunogen:
Synthetic peptide corresponding to C-terminal human PEN2.

MW: ~ 12 kDa

Swis Prot.: Q9NZ42

Purification & Purity:
Protein A affinity purified.

Format:
Recombinant Rabbit Monoclonal Antibody. 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.

Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

For research use only, not for use in diagnostic procedure.