PER1 polyclonal, anti-human, mouse, rat

Quantity: 100 µg

Background:
PER1(Period, Drosophila, Homolog of), also known as PER or RIGUI, is a protein that in humans is encoded by the PER1 gene. By fluorescence in situ hybridization, Sun et al.(1997) mapped the human PER1 gene to 17p12. Sun et al.(1997) found that in mouse retina, the expression of rigui oscillated over a 24-hour period, with highest expression at onset of dark in a 12-hour light/dark cycle, i.e., expression rose during the light period and fell during the dark period. RNA abundance of rigui changed 2.9-fold between highest and lowest levels in mouse retina. Shigeyoshi et al.(1997) examined the effects of light on rigui, designated mouse Per1 by them, which exhibits robust rhythmic expression in the SCN. They found that Per1 is rapidly induced by short duration exposure to light at levels sufficient to reset the clock. Von Gall et al.(2002) demonstrated that cycling expression of the clock gene Per1 in rodent pituitary cells depends on the heterologous sensitization of the adenosine A2B receptor, which occurs through the nocturnal activation of melatonin mt1 receptors.

Description:
Rabbit IgG polyclonal antibody for Period circadian protein homolog 1 (PER1) detection. Tested with WB in Human, Mouse, Rat.

Synonyms:
Circadian clock protein PERIOD 1 antibody, Circadian clock protein PERIOD1 antibody, Circadian pacemaker protein Rigui antibody, hPER 1 antibody, hPER antibody, hPER1 antibody, KIAA0482 antibody, MGC88021 antibody, PER 1 antibody, PER antibody, PER1 antibody, PER1 protein antibody, PER1_HUMAN antibody, Period 1 antibody, Period circadian protein homolog 1 antibody, Period drosophila homolog of antibody, Period homolog 1 antibody, Period1 antibody, RIGUI antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
A synthetic peptide corresponding to a sequence at the N-terminus of human PER1(289-302aa RDFTQEKSVFCRIR), identical to the related mouse sequence, and different from the related rat sequence by one amino acid.A synthetic peptide corresponding to a sequence at the N-terminus of human PER1(289-302aa RDFTQEKSVFCRIR), identical to the related mouse sequence, and different from the related rat sequence by one amino acid.

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human, rat .
Predicted to work with: mouse.

Applications: WB

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.