PER2 polyclonal, anti-human

Quantity: 100 µg

Background:
The PER2 gene encodes the period circadian protein homolog 2 protein in humans. This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. PER2 is mapped to 2q37.3. It has been showed that PER2 can positively stimulate activity of the Bmal1-Npas2 transcription complex and, in turn, Npas2 transcriptionally regulates delta-aminolevulinate synthase. PER2 is involved in a negative-feedback loop that attenuates estrogen stimulation and links the circadian cycle to estrogen receptor signaling. The rhythmic levels of PER2 are critical for circadian oscillations in cells and intact organisms. What’s more, the PER2 gene also functions in tumor suppression by regulating DNA damage-responsive pathways.

Description:
Rabbit IgG polyclonal antibody for Period circadian protein homolog 2 (PER2) detection. Tested with WB in Human.

Synonyms:
Circadian clock protein PERIOD 2 antibody, FASPS antibody, FASPS1 antibody, hPER 2 antibody, hPER2 antibody, KIAA0347 antibody, OTTHUMP00000164476 antibody, PER 2 antibody, PER2 antibody, PER2_HUMAN antibody, Period 2 antibody, Period 2 isoform 1 antibody, Period circadian clock 2 antibody, Period circadian protein 2 antibody, Period circadian protein homolog 2 antibody, Period homolog 2 (Drosophila) antibody, Period homolog 2 antibody, Period2 antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
E.coli-derived human PER2 recombinant protein (Position: N13-K330). Human PER2 shares 84% and 83% amino acid (aa) sequence identity with mouse and rat PER2, respectively.

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human

Applications: WB

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.