PER2 Polyclonal Antibody

Background:
This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic Nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. Polymorphisms in this gene may increase the risk of getting certain cancers and have been linked to sleep disorders.

Research Area: Cancer, Cardiovascular, Epigenetics and Nuclear Signaling, Metabolism, Neuroscience, Signal transduction

Synonyms:
Circadian clock protein PERIOD 2, FASPS, FASPS1, hPER 2, hPER2, KIAA0347, OTTHUMP00000164476, PER 2, PER2, PER2, Period 2, Period 2 isoform 1, Period circadian clock 2, Period circadian protein 2, Period circadian protein homolog 2, Period homolog 2 (Drosophila), Period homolog 2, Period, Drosophila, homolog of, 2, Period2

Immunogen: Synthetic peptide of human PER2

Swissprot: O15055
Gene Accession: NP_073728

Purification Method: Affinity purification

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Concentration: 0.6 mg/mL
Dilution: IHC 1:100-1:300

Storage:
Store at -20°C. Avoid freeze / thaw cycles.

Alternative for product with catalog number:
sc-7728/sc-25363