PER2 Polyclonal Antibody

Background:
This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. Polymorphisms in this gene may increase the risk of getting certain cancers and have been linked to sleep disorders.

Research Area: Cancer, Cardiovascular, Epigenetics and Nuclear Signaling, Metabolism, Neuroscience, Signal transduction

Synonyms:
PER2, FASPS, FASPS1

Immunogen: Recombinant fusion protein of human PER2 (NP_073728.1).

Swissprot: O15055
Gene ID: 8864

Calculated MW: 45 kDa/136 kDa
Observed MW: 150 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Concentration: 1 mg/mL
Dilution: "WB 1:500-1:2000"

Storage:
Store at -20°C. Avoid freeze / thaw cycles.