Peripherin (clone 7C5), anti-human, mouse, rat
€442.00
In stock
SKU
253203
Catalog Nr.: 253203
Size: 0.1 ml
Isotype: Mouse IgG1
Applications: E, WB, IF
Datasheet
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Size: 0.1 ml
Isotype: Mouse IgG1
Applications: E, WB, IF
Datasheet
Request Information
Protein Family: Cytoskeleton Proteins
Pathway and Disease: Cancers, Endocrine System, Nervous and Sensory Systems
Description:
Peripherin is a ~57kDa intermediate filament subunit found initially in sensory neurons of the peripheral nervous systems, which gives the protein its name. Subsequently, peripherin was found in some sensory and other neurons of the central nervous system and also in PC12 cells. Peripherin is also expressed in certain neuroendocrine tumors and in the insulin producing cells of the pancreas. Peripherin belongs to the Class III family of intermediate filament subunits which also includes vimentin, glial fibrillary acidic protein (GFAP) and desmin. In contrast to the neurofilaments, peripherin is strongly up-regulated after nerve injury. Antibodies to peripherin can be used in identifying, classifying, and studying neurons throughout the nervous system. Peripherin is also a good diagnostic marker for ballooned axons seen in Lou Gehrig's disease (Amyotrophic lateral sclerosis) and some neuronally derived tumors. Autoantibodies to peripherin are frequently seen in the sera of patients with diabetes. Peripherin is not related to peripherin/RDS, a protein of the photoreceptor outer membrane mutations of which are causative of certain forms of slow retinal degeneration.
Alternate Names: Peripherin, Prph, Prph1
Application Notes: Product 253203 works well with sample fixed with paraformaldehyde. E: 1:1,000-1:5,000; WB:1:1,000; IF: 1:200
Accession No.: P21807
Antigen: Recombinant rat peripherin expressed in E. coli
Format: Each vial contains 0.1 ml IgG in PBS pH7.4 with 0.065% sodium azide. Antibody was purified by PEG precipitation.
Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Pathway and Disease: Cancers, Endocrine System, Nervous and Sensory Systems
Description:
Peripherin is a ~57kDa intermediate filament subunit found initially in sensory neurons of the peripheral nervous systems, which gives the protein its name. Subsequently, peripherin was found in some sensory and other neurons of the central nervous system and also in PC12 cells. Peripherin is also expressed in certain neuroendocrine tumors and in the insulin producing cells of the pancreas. Peripherin belongs to the Class III family of intermediate filament subunits which also includes vimentin, glial fibrillary acidic protein (GFAP) and desmin. In contrast to the neurofilaments, peripherin is strongly up-regulated after nerve injury. Antibodies to peripherin can be used in identifying, classifying, and studying neurons throughout the nervous system. Peripherin is also a good diagnostic marker for ballooned axons seen in Lou Gehrig's disease (Amyotrophic lateral sclerosis) and some neuronally derived tumors. Autoantibodies to peripherin are frequently seen in the sera of patients with diabetes. Peripherin is not related to peripherin/RDS, a protein of the photoreceptor outer membrane mutations of which are causative of certain forms of slow retinal degeneration.
Alternate Names: Peripherin, Prph, Prph1
Application Notes: Product 253203 works well with sample fixed with paraformaldehyde. E: 1:1,000-1:5,000; WB:1:1,000; IF: 1:200
Accession No.: P21807
Antigen: Recombinant rat peripherin expressed in E. coli
Format: Each vial contains 0.1 ml IgG in PBS pH7.4 with 0.065% sodium azide. Antibody was purified by PEG precipitation.
Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
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