Perlecan (clone A76), anti-human, bovine

Protein Family: Proteoglycans, Receptors and Channels

Pathway and Disease: Cell Motility, Signaling Molecules and Interaction,

Description:
Perlecan is an extracellular matrix proteoglycan. It has a large core protein of 400-450 kDa and is often produced with heparan sulfate side chains. Perlecan is found in basement membranes where it contributes to the permeability characteristics, serves as a substrate for vascular cells and binds growth factors involved in vascular remodelling. This antibody is highly specific for perlecan. There is no evidence for cross-reactivity with other connective tissue proteins (vitronectin, fibronectin, elastin, collagen, laminin This antibody reacts with human perlecan. Other species have not been tested.

Alternate Names: HSPG, PLC, Basement memebrane-specific heparan sulfate proteoglacan core protein [precursor]

Application Notes: Product Cat. No. 250260 can be used in immunoprecipitation, ELISA and immunostaining of frozen PLP-fixed sections of bovine and human tissues. Product Cat. No. 250260 is more sensitive than Product Cat. No. 250258 or Product Cat. No. 250259 in ELISA. E: 1:8,000; WB: 1:500; IHC: 1:100

Accession No.: P98160

Antigen: Lysed bovine corneal endothelial cells and extracellular matrix

Format: Each vial contains 0.2 mg IgG in 0.2 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-A/G affinity chromatography.

Storage:
Store at 4°C. Product is guaranteed 6 months from the date of shipment.