Peroxiredoxin 1 polyclonal, anti-human, mouse, rat

Quantity: 100 µg

Background:
PRDX1(Peroxiredoxin 1), also called PRX1, PAGA or NKEFA, is a thiol reductase that plays critical roles in oxidative and thermal stress defense mechanisms through its abilities to metabolize H2O2 and act as a molecular chaperone, respectively. This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The PRDX1 gene is mapped on 1p34.1. Prdx1 was expressed in differentiating motor neuron cells in developing embryonic chicken and mouse spinal cords. mmunoprecipitation analysis showed that GDE2 interacted directly with PRDX1 in embryonic chicken spinal cord extracts and in transfected HEK293T cells. This protein may have a proliferative effect and play a role in cancer development or progression. In differentiating spinal cord, Prdx1 was required to activate Gde2 by reducing an intramolecular cystine bridge between the Gde2 N- and C-terminal domains. An intramolecular disulfide bond between the GDE2 N- and C-terminal domains inhibits GDE2 function, and that reduction of this cystine by PRDX1 activates GDE2 for the induction of motor neuron differentiation.

Description:
Rabbit IgG polyclonal antibody for Peroxiredoxin-1 (PRDX1) detection. Tested with WB in Human, Mouse, Rat.

Synonyms:
Hbp23 antibody, Heme binding 23 kDa protein antibody, Macrophage 23 Kd stress protein antibody, Macrophage 23kDa stress protein antibody, Macrophase stress protein 22kDa antibody, Macrophase stress protein 23 kd antibody, MSP23 antibody, Natural killer cell enhancing factor A antibody, Natural killer cell-enhancing factor A antibody, Natural killer enhancing factor A antibody, NKEF A antibody, NKEF-A antibody, NkefA antibody, OSF3 antibody, Osteoblast specific factor 3 antibody, PAG antibody, Paga antibody, PAGB antibody, Peroxiredoxin-1 antibody, Prdx 1 antibody, Prdx1 antibody, PRDX1_HUMAN antibody, Proliferation associated gene A antibody, Proliferation associated protein PAG antibody, Proliferation-associated gene protein antibody, PrxI antibody, Tdpx 2 antibody, Tdpx2 antibody, TDX2 antibody, Thioredoxin dependent peroxide reductase 2 antibody, Thioredoxin peroxidase 2 antibody, Thioredoxin-dependent peroxide reductase 2 antibody, TPxA antibody, Trx dependent peroxide reductase 2 antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
A synthetic peptide corresponding to a sequence at the C-terminus of human Peroxiredoxin 1(185-199aa KPDVQKSKEYFSKQK), different from the related rat and mouse sequences by one amino acid.A synthetic peptide corresponding to a sequence at the C-terminus of human Peroxiredoxin 1(185-199aa KPDVQKSKEYFSKQK), different from the related rat and mouse sequences by one amino acid.

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human, rat .
Predicted to work with: mouse.

Applications: WB

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.