Peroxiredoxin 2 polyclonal, anti-human, mouse, rat

Quantity: 100 µg

Background:
PRDX2(peroxiredoxin 2) also known as NKEFB, PRP, PRX2, PRXII or TPX1, is a protein that in humans is encoded by the PRDX2 gene. This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein may play an antioxidant protective role in cells, and may contribute to the antiviral activity of CD8(+) T-cells. This protein may have a proliferative effect and play a role in cancer development or progression. The Prdx2 -/- mice were healthy in appearance and fertile. Choi et al.(2005) demonstrated that PRDX2 is a negative regulator of PDGF signaling. Prx II deficiency results in increased production of peroxide, enhanced activation of PDGF receptor and phospholipase C-gamma-1, and subsequently increased cell proliferation and migration in response to PDGF. PRX2 accounted for about half of the thioredoxin activity in parasite extracts, and PRX2 expression was increased in the presence of chloroquine, regardless of P. falciparum strain susceptibility to the drug. 

Description:
Rabbit IgG polyclonal antibody for Peroxiredoxin-2 (PRDX2) detection. Tested with WB in Human, Mouse, Rat.

Synonyms:
MGC4104 antibody, Natural killer cell enhancing factor B antibody, Natural killer cell-enhancing factor B antibody, Natural Killer Enhancing Factor B antibody, NKEF B antibody, NKEF-B antibody, NKEFB antibody, Peroxiredoxin-2 antibody, PRDX 2 antibody, PRDX2 antibody, PRDX2_HUMAN antibody, PrP antibody, PRX2 antibody, PRXII antibody, TDPX1 antibody, Thiol Specific Antioxidant 1 antibody, Thiol specific antioxidant protein antibody, Thiol-specific antioxidant protein antibody, Thioredoxin Dependent Peroxide Reductase 1 antibody, Thioredoxin peroxidase 1 antibody, Thioredoxin-dependent peroxide reductase 1 antibody, Torin antibody, TPX1 antibody, TSA antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
A synthetic peptide corresponding to a sequence at the C-terminus of human Peroxiredoxin 2(181-198aa DTIKPNVDDSKEYFSKHN), identical to the related mouse and rat sequences.A synthetic peptide corresponding to a sequence at the C-terminus of human Peroxiredoxin 2(181-198aa DTIKPNVDDSKEYFSKHN), identical to the related mouse and rat sequences.

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human, rat .
Predicted to work with: mouse.

Applications: WB

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.