Peroxiredoxin 2 polyclonal, anti-human, mouse, rat

Background:
The peroxiredoxin (PRX) family comprises six antioxidant proteins, PRX I, II, III, IV, V and VI, which protect cells from reactive oxygen species (ROS) by preventing the metal-catalyzed oxidation of enzymes. The PRX proteins primarily utilize thioredoxin as the electron donor for antioxidation, although they are fairly promiscuous with regard to the hydroperoxide substrate. In addition to protection from ROS, peroxiredoxins are also involved in cell proliferation, differentiation and gene expression. PRX I, II, IV and VI show diffuse cytoplasmic localization, while PRX III and V exhibit distinct mitochondrial localization. PRX II is expressed in testis, while PRX III shows expression in lung. PRX I, II and III are overexpressed in breast cancer and may be involved in its development or progression. Upregulated protein levels of PRX I and II in Alzheimer's disease (AD) and Down syndrome (DS) indicate the involvement of PRX I and II in their pathogenesis.

Alternative Name:
NKEF-B, TSA, PRDX2, Epididymis secretory sperm binding protein Li 2a, HEL S 2a, MGC4104, Natural killer cell enhancing factor B, Natural killer cell-enhancing factor B, Natural Killer Enhancing Factor B, NKEF B, NKEF-B, NKEFB, Peroxiredoxin-2, PRDX 2, PRDX2, PRDX2, PrP, PRX2, PRXII, PTX1, TDPX1, Thiol Specific Antioxidant 1, Thiol specific antioxidant protein, Thiol-specific antioxidant protein, Thioredoxin Dependent Peroxide Reductase 1, Thioredoxin peroxidase 1, Thioredoxin-dependent peroxide reductase 1, Torin, TPX1, TSA,

Application Dilution:
WB:1:1,000-1:2,000
ICC:1:100-1:500
IHC:1:50-1:200
FC:1:10-1:50

Specificity: Peroxiredoxin 2 polyclonal antibody detects endogenous levels of Peroxiredoxin 2 protein.

Immunogen:
recombinant protein

MW: 22 kDa

Swiss-Prot: P32119(Human) Q61171(Mouse) P35704(Rat)

Purification & Purity:
ProA affinity purified

Format:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Storage:
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

For research use only, not for use in diagnostic procedure.