Peroxiredoxin 3 polyclonal, anti-human, mouse, rat

Quantity: 100 µg

Background:
PRDX3(peroxiredoxin 3) also known as AOP-1, MER5, SP-22 or PRX3, is localized exclusively in mitochondria. The deduced 256-amino acid human AOP1 protein shares 86% amino acid sequence similarity with mouse Aop1, and significant similarity with both the human proliferation-associated gene A product and the mouse stress-induced peritoneal macrophage protein Msp23. The PRDX3 gene is mapped on 10q26.11. Expression of PRDX3 is induced by MYC and is reduced in c-myc -/- cells. Chromatin immunoprecipitation analysis spanning the entire PRDX3 genomic sequence revealed that MYC binds preferentially to a 930-bp region surrounding exon 1. Results using mitochondria-specific fluorescent probes demonstrated that PRDX3 is essential for maintaining mitochondrial mass and membrane potential in transformed rat and human cells. These data provided evidence that PRDX3 is a MYC target gene that is required to maintain normal mitochondrial function.

Description:
Rabbit IgG polyclonal antibody for Thioredoxin-dependent peroxide reductase, mitochondrial (PRDX3) detection. Tested with WB, IHC-P in Human, Mouse, Rat.

Synonyms:
Antioxidant Protein 1 antibody, AOP 1 antibody, AOP-1 antibody, AOP1 antibody, HBC189 antibody, MER 5 antibody, MER5 antibody, MGC104387 antibody, MGC24293 antibody, mitochondrial antibody, Mitochondrial thioredoxin dependent peroxide reductase antibody, peroxiredoxin 3 antibody, PeroxiredoxinIII antibody, Peroxiredoxin-3 antibody, Peroxiredoxin3 antibody, PRDX 3 antibody, PRDX3 antibody, PRDX3_HUMAN antibody, PRO1748 antibody, Protein MER5 homolog antibody, PRX III antibody, PRXIII antibody, Prx-III antibody, PRX3 antibody, SP 22 antibody, SP-22 antibody, SP22 antibody, Thioredoxin dependent peroxide reductase mitochondrial antibody, Thioredoxin dependent peroxide reductase precursor antibody, Thioredoxin-dependent peroxide reductase antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
A synthetic peptide corresponding to a sequence at the C-terminus of mouse Peroxiredoxin 3(240-257aa TIKPSPTASKEYFEKVHQ), identical to the related rat sequence, and different from the related human sequence by three amino acids.A synthetic peptide corresponding to a sequence at the C-terminus of mouse Peroxiredoxin 3(240-257aa TIKPSPTASKEYFEKVHQ), identical to the related rat sequence, and different from the related human sequence by three amino acids.

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human, rat .
Predicted to work with: mouse.

Applications: WB, IHC-P

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.