PF4 polyclonal, anti-human

Quantity: 100 µg

Background:
CXCL4, Chemokine(C-X-C motif) ligand 4, is a 70-amino acid protein that is released from the alpha-granules of activated platelets and binds with high affinity to heparin. CXCL4 belongs to the CXC chemokine family. The CXCL4 gene contains 3 exons spanning approximately 1 kb. The gene is encoded on a 10-kb EcoRI fragment of genomic DNA. By in situ hybridization, the CXCL4 gene is mapped to chromosome 4q12-q21. Its major physiologic role appears to be neutralization of heparin-like molecules on the endothelial surface of blood vessels, thereby inhibiting local antithrombin III activity and promoting coagulation. As a strong chemoattractant for neutrophils and fibroblasts, PF4 probably has a role in inflammation and wound repair.

Description:
Rabbit IgG polyclonal antibody for Platelet factor 4 (PF4) detection. Tested with WB, IHC-P in Human.

Synonyms:
C-X-C motif chemokine 4 antibody, Chemokine(C X C motif) ligand 4 antibody, Chemokine(CXC motif) ligand 4 antibody, CXCL 4 antibody, CXCL4 antibody, Iroplact antibody, MGC138298 antibody, Oncostatin A antibody, Oncostatin-A antibody, OncostatinA antibody, PF 4 antibody, PF-4 antibody, PF4 antibody, Platelet factor 4 antibody, PLF4_HUMAN antibody, SCYB 4 antibody, SCYB4 antibody, short form antibody, Small inducible cytokine subfamily member 4 antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
A synthetic peptide corresponding to a sequence at the C-terminus of human PF4(85-101aa DLQAPLYKKIIKKLLES).

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human

Applications: WB, IHC-P

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.