PFN2 Polyclonal Antibody

Background:
The protein encoded by this gene is a ubiquitous actin monomer-binding protein belonging to the profilin family. It is thought to regulate actin polymerization in response to extracellular signals. There are two alternatively spliced transcript variants encoding different isoforms described for this gene. Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG.

Research Area: Signal Transduction

Synonyms:
D3S1319E, PFL, PFN 2, Pfn2, PROF2, Profilin II, Profilin-2, Profilin2, ProfilinII

Immunogen: Synthetic peptide of human PFN2

Swissprot: P35080
Gene Accession: NP_444252

Calculated MW: 15 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Concentration: 0.3 mg/mL
Dilution: WB 1:500-1:2000, IHC 1:25-1:100

Storage:
Store at -20°C. Avoid freeze / thaw cycles.