PGC1α/β polyclonal, anti-human, mouse, rat

Background:
Transcription factors exert their effects by associating with co-activator or corepressor proteins. The co-activator complexes are thought to be constitutively active, requiring only proper positioning in the genome to initiate transcription. Co-activators include the steroid receptor coactivator (SRC) and CREB binding protein (CBP) families that contain histone acetyltransferase (HAT) activity, which modifies chromatin structure. PPARgamma co-activator-1 (PGC-1) is a transcriptional cofactor of nuclear respiratory factor-1 (NRF-1), PPARbeta, PPARalpha and other nuclear receptors that is induced by exposure to cold temperatures and is involved in regulating thermogenic gene expression, protein uncoupling, and mitochondrial biogenesis. PGC-1 has a low inherent transcriptional activity when it is not bound to a transcription factor. Docking of PGC-1 to PPARgamma stimulates an apparent conformational change that then enables PGC-1 to bind to and assemble into complexes, which include the additional cofactors SRC-1 and CBP/p300, and results in a large increase in transcriptional activity.

Alternative Name:
PGC-1-alpha, PPAR-gamma coactivator 1-alpha, PPARGC-1-alpha, PPARGC1A, PGC-1-beta, PPAR-gamma coactivator 1-beta, PPARGC-1-beta, PPARGC1B, LEM6, Ligand effect modulator 6, PERC, Peroxisome proliferative activated receptor, gamma, coactivator 1 alpha, Peroxisome proliferative activated receptor, gamma, coactivator 1, Peroxisome proliferator activated receptor gamma coactivator 1 alpha, peroxisome proliferator-activated receptor gamma coactivator 1 beta, Peroxisome proliferator-activated receptor gamma coactivator 1-alpha, Peroxisome proliferator-activated receptor gamma coactivator 1-beta, peroxisome proliferator-activated receptor gamma, coactivator 1 beta, PGC 1 (alpha), PGC 1 alpha, PGC 1v, PGC-1(beta), PGC-1-alpha, PGC-1-beta, PGC-1-related estrogen receptor alpha coactivator, PGC1, PGC1(alpha), PGC1A, PGC1v, PPAR gamma coactivator 1 alpha, PPAR gamma coactivator 1 alpha 3 ligand effect modulator 6, PPAR gamma coactivator 1, PPAR gamma coactivator variant form, PPAR gamma coactivator-1beta, PPAR-gamma coactivator 1-alpha, PPAR-gamma coactivator 1-beta, PPARGC 1 alpha, PPARGC-1-alpha, PPARGC-1-beta, PPARGC1, PPARGC1A, Ppargc1b, PRGC1, PRGC2,

Application Dilution:
WB:1:1,000

Specificity: PGC1α/β polyclonal antibody detects endogenous levels of PGC1α/β protein.

Immunogen:
recombinant protein

MW: 113 kDa

Swiss-Prot: Q86YN6(Human) Q9UBK2(Human) 415302(Mouse) O70343(Mouse) Q8VHJ7(Mouse) Q811R2(Rat) Q9QYK2(Rat)

Purification & Purity:
ProA affinity purified

Format:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Storage:
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

For research use only, not for use in diagnostic procedure.